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Original Article

Year: 2011 | Volume: 1 | Issue 1 | Page: 6 - 10

Multidrug resistant Acinetobacter isolates from patients admitted to Kolar

Rekha S, Gokul BN, Beena PM, Prasad SR, Department of Microbiology, Sri Devaraj Urs Medcal College, Kolar.

Objectives: To study the antimicrobial susceptibility pattern of Acinetobacter isolated from various clinical specimens.
Methods: A total of 34 isolates of Acinetobacter were obtained from 4086 samples over a period of 7 months (Jan – July 2010). Antimicrobial susceptibility testing was done by Kirby – Bauer’s disc diffusion method with commercially available discs on Muller Hinton agar plates. The zones of inhibition were interpreted for antibiotic sensitivity as per the CLS1 guidelines 2010.
Results: Acinetobacter was isolated predominantly from tracheal aspirates (38%) followed by sputum 35%, pus from surgical site infections (12%), blood (9%) and urine (6%). Majority of the isolates were from the Intensive care unit (ICU) patients  26/34 (76.5%), followed by those isolated from patients hospitalized in the wants 6/34(17.6%). Community acquired infections were also seen in 2(5.9%) outpatient department (OPD) cases. Overall 70.6% of the isolates were sensitive to Imipenem followed by Piperacillin-Tazobactam (26.5%), Gentamicin (20.6%), Piperacillin. Amikacin and Ciprofloxacin (17.6%) each. Tetracycline (14.7%), Trimethoprim-sulpámethoxazole and Ceftazidime (5.9%) each. Most of the isolates (74%) were multidrug resistant.
Conclusions: Acinetobacter is emerging as a predominant health care associated multidrug resistant pathogen, especially in the ICUs with increasing resistance to carbapenems. This is a major concern as untreatable infections by this organism may contribute to increased morbidity and mortality.
KEY WORDS: Acinetobacter multidrug resistance nosocomial infection

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